I've only worn them for one run so far, but they were great! I usually have blistering on the medial side of my big toe and the tip of my second toe. I didn't have any discomfort during or after my run in these socks. Definitely, recommend!
Multiple days with greater than 35,000 steps walking in New York City, and NO BLISTERS! This is my 3rd pair of Wrightsocks, and I absolutely love them!